A2M Therapy in Murray, Utah

A2M is a large protease inhibitor found in your blood plasma. Think of it as your body’s biological defense shield against harmful enzymes that digest cartilage and connective tissue. When joints are injured or inflamed, the body produces catabolic enzymes such as:

• MMPs (Matrix Metalloproteinases)
• ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs)

These enzymes break down collagen and aggrecan, leading to progressive cartilage thinning, joint space narrowing, and painful arthritis.

A2M binds to these enzymes and locks them in, rendering them inert. This stops the “chemical cascade” that damages cartilage and prevents further joint degradation.

Recent studies, including those from Stanford University and other orthopedic research centers, show that:

• A2M can bind and neutralize up to 95% of cartilage-destroying enzymes in the joint
• Patients who receive A2M therapy show reduced biomarkers of cartilage loss (e.g., CTX-II, MMP-13)
• It may also suppress inflammatory cytokines like IL-1β and TNF-α

In advanced applications, we use MRI imaging and biomarker testing to determine whether A2M is the right treatment based on your joint’s enzyme activity levels.

A2M is best suited for early to moderate joint damage and works as both a standalone and adjunctive therapy. Conditions include:

• Osteoarthritis (knee, hip, shoulder, ankle, spine)
• Meniscal degeneration or “silent” cartilage fraying
• Post-traumatic arthritis (after ACL, rotator cuff, etc.)
• Labral damage in hips or shoulders
• Joint pain that worsens with load or repetition
• Failed cortisone or HA injections

Athletes looking to protect joints under repetitive strain

How the Procedure Works

1. Evaluation

We assess your symptoms, function, joint imaging (MRI or X-ray), and risk factors for degeneration.

2. Blood Collection & Processing

A small amount of your blood is drawn and spun in a centrifuge using proprietary filters and systems to isolate and concentrate your A2M protein.

3. Targeted Injection

Your A2M is injected directly into the joint capsule using ultrasound guidance to ensure accuracy. We can combine it with PRP, ozone, or Prolotherapy depending on your joint’s condition.

Time Required: 45–60 minutesNumber of Sessions: 1–2 per year in most cases

Why A2M is Different from Cortisone or HA

Cortisone and gel shots are short-term symptom relievers, while A2M is a long-term cartilage-preserving solution.

Combining A2M with PRP, Ozone, or Prolotherapy

At our clinic, we often combine A2M with:

• PRP: Delivers growth factors to regenerate cartilage
• Prolotherapy: Stimulates ligament repair and joint stability
• Ozone: Enhances anti-inflammatory response and oxygenation

This multi-therapy approach allows us to tailor your regenerative program for both protection and regeneration.

Results & Expectations

Timeline:

• Days 1–7: Minor soreness
• Weeks 2–4: Inflammation reduction
• Month 1–3: Pain relief and improved joint mechanics
• Long term: Stabilized or slowed arthritis progression

Maintenance:

Most patients only need 1–2 sessions per year, making this a sustainable and cost-effective therapy compared to surgery or long-term medication.

Ideal Candidates for A2M Therapy

You’re likely a great candidate if you:

• Are age 30–70 with early signs of arthritis
• Want to avoid joint replacement surgery
• Have cartilage fraying or thinning on MRI
• Are active but limited by pain
• Have not responded well to steroid or gel injections
• Are looking for a biologic, natural alternative

Patients with advanced, bone-on-bone arthritis may need additional therapies or surgical consultation.

Testimonials from Real Patients

“I had cartilage loss in my knees and was told I’d need a replacement. A2M gave me a year of pain relief without surgery.” – Tom S.

“Combining PRP and A2M was a game changer. My shoulder pain is 90% better and I’m lifting again.” – Angela M.

“This therapy helped me keep doing CrossFit into my 50s. Thank you for offering natural options.” – Chris D.